Crespi & Badcock (C&B) present an appealing and parsimonious synthesis arguing that schizophrenia and autism are differentially regulated by maternal versus paternal genomic imprinting, respectively. We argue that animal models related to schizophrenia and autism provide a useful platform to explore the mechanisms outlined by C&B. We also note that schizophrenia and autism share certain risk factors such as advanced paternal age. Apart from genomic imprinting, copy number variants related to advanced paternal age may also contribute to the differential trajectory (...) of brain development associated with autism and schizophrenia. (shrink)

Due in part to a growing realization of the importance of the role that retailing plays in the marketing channel, and to the increasing numbers of college graduates being employed by retailers, growing attention is being placed on business students'' ethical perceptions of retailing practices. This study continues this focus by examining the ethical perceptions of collegiate business students attending two different universities which likely represent two different microcultures — conservative evangelical Protestant and secular.The results suggest that ethical perceptions may (...) vary between the students attending two universities which likely represent differing microcultures. The students attending the conservative evangelical Protestant university appear to possess ethical perceptions which are significantly more ethical than those of students attending the public university. Evidence was observed, therefore, which suggests that ethical perceptions may vary across students from differing microcultures. (shrink)

By the death, last summer, of Jack Robson, the world of utilitarian studies and a wider world of scholarship on both sides of the Atlantic lost one of their most distinguished figures. It would not be appropriate here, even if it were possible now, to attempt a full and measured assessment of his work. Writing only a few months after the news of his death, while the sense of loss is still so sharp for all his many friends, two things (...) are possible. Something can and should be said to acknowledge and celebrate Robson's achievement as a scholar; and to this can be added some personal recollections of one whose human qualities were as outstanding as his scholarship. (shrink)

Cancer and its treatment pose challenges that affect not only patients but also their significant others, including intimate partners. Accumulating evidence suggests that couples’ ability to communicate effectively plays a major role in the psychological adjustment of both individuals and the quality of their relationship. Two key conceptual models have been proposed to account for how couple communication impacts psychological and relationship adjustment: the social-cognitive processing (SCP) model and the relationship intimacy (RI) model. These models posit different mechanisms and outcomes, (...) and thus have different implications for intervention. The purpose of this project is to test and compare the utility of these models using comprehensive and methodologically rigorous methods. Aims are: (1) to examine the overall fit of the SCP and RI models in explaining patient and partner psychological and relationship adjustment as they occur on a day-to-day basis and over the course of 1 year; (2) to examine the fit of the models for different subgroups (males vs. females, and patients vs. partners); and (3) to examine the utility of various methods of assessing communication by examining the degree to which baseline indices from different measurement strategies predict self-reported adjustment at 1-year follow up. The study employs a longitudinal, multi-method approach to examining communication processes including: standard self-report questionnaires assessing process and outcome variables collected quarterly over the course of 1 year; smartphone-based ecological momentary assessments to sample participant reports in real time; and laboratory-based couple conversations from which we derive observational measures of communicative behavior and affective expression, as well as vocal indices of emotional arousal. Participants are patients with stage II-IV breast, colon, rectal, or lung cancer and their spouses/partners, recruited from two NCI-designated comprehensive cancer centers. Results will be published in scientific journals, presented at scientific conferences, and conveyed to a larger audience through infographics and social media outlets. Findings will inform theory, measurement, and the design and implementation of efficacious interventions aimed at optimizing both patient and partner well-being. (shrink)

John Fleming , later professor in Aberdeen and Edinburgh, made his combative contribution to natural history between 1812 and 1832. As an Edinburgh student he had followed Robert Jameson's ‘Wernerian’ lead. His earliest publications, from 1813, expressed what was to be a lifelong hostility to the work of James Hutton. Yet his own thinking moved increasingly towards a ‘uniformitarian’ as opposed to a ‘catastrophist’ view of earth history. His Philosophy of Zoology embodied criticism of Cuvier. More dramatically, he became (...) embroiled in controversy with Buckland and later with Conybeare. By then the ‘uniformitarian’ hypothesis had been adopted by Lyell, with whom Fleming was in close touch from the mid-1820s. Fleming may have had some grounds for feeling that his priority in advocating uniformitarianism was later overlooked. His History of British Animals included a preface in which he elaborated his earlier hypothesis as to ‘revolutions … in the animal kingdom’ correlated with six geological epochs. Tension had then developed in Fleming's relationship with Jameson, and the early 1830s found him in a mood of increasing frustration. Reconciliation with Buckland and approval by Sedgwick still left ‘the Zoological Ishmael’ feeling that his advancement in the scientific world was blocked, perhaps permanently. In historical perspective Fleming may be seen as a minor but not insubstantial figure in the scientific landscape of the early nineteenth century. (shrink)

Please imagine a long fuse hanging down from the ceiling. It is a carefully woven tube of fabric that holds a core of gunpowder. We note that it is beautifully made, with brightly colored threads intertwined with the coarser bare cotton. It a masterpiece of the modern weaver's art.

Locke bases his moral and political philosophy on his doctrine of the ‘law of nature’. Scholars have debated the content and grounding of this law and its relationship to Christian theology. The ambiguities of the Lockean natural law’s content are traceable to an unclear grammatical construction in a crucial passage of the Treatises of Government, which can be resolved by following out a related set of arguments in that work. The ambiguities of the Lockean natural law’s grounding can then be (...) resolved by the hypothesis, strongly supported by textual evidence, that Locke relies tacitly on the reasoning of a parallel passage in Hobbes. Lockean natural law rests on neither atheistic nor specifically Christian premises but on a hypothetical natural theology. Locke’s conclusions from that natural theology represent an attempt to follow out Hobbesian logic while also tightening it up on one important point on which Hobbes himself appears to vacillate. (shrink)

Nevertheless, the problem of nuclear waste disposal is not insoluble. Good technical solutions have existed for at least 20 years, but for political reasons none has ever been implemented. This could be changing. New accelerator-based technical solutions are perhaps more politically acceptable. This column is about this emerging technology.

A reassessment of Aquinas’s doctrine of divine infinity, particularly in the light of the previous history of the concept within Western philosophy and theology. From the critical perspective provided by this history the central place which has been claimed for it in Aquinas’s thinking is questioned, as are also its originality and coherence. The notion that the doctrine of divine infinity was introduced to Western thought by Judaeo‐Christianity is rejected; from Anaximander onwards it had been a central concept in Greek (...) philosophy. Aristotle however had rejected it so effectively that, for several centuries afterwards, it seems to have led an ‘underground’ existence until it finally surfaces again in ‘Gnostic’ and related currents of thought. It is from these circles that it finally, and after some resistance, patchily entered orthodox Christian thinking. Likewise Plotinus was not the source of the doctrine, as some have claimed; historical precedence must be given to the Gnostics. Neoplatonism never, despite the prestige of Plotinus, fully accepted the doctrine; in Proclus it is a subordinate emanation from the One, which is beyond Infinity and Infinitude. Nor, because of the influence of Aristotle, does Islamic Neoplatonized Aristotelianism endorse the doctrine. Aquinas’s commitment to it seems to stem from the impact of John of Damascus’s stress upon the doctrine, the translation of whose work greatly influenced Western theology from the late twelfth century onward, together with his need to distance himself from the restrictions of the divine power and freedom found in the Arabic Aristotelian philosophers, whom, in general, he regarded as philosophical authorities. But his position on the doctrine is flawed by equivocation and self‐contradiction, flowing from his attempt to reconcile Christian personalist theism with Neoplatonized Aristotleain necessitarian monism. (shrink)

Already known for his penetrating, and sometimes idiosyncratic, interpretations of the later Wittgenstein, John Hunter, of University College, Toronto, now offers eight essays on independent topics. Each of the essays stands on its own, but they are clearly the work of a single mind and together constitute a sustained contribution to current discussion of that area of metaphysics sometimes called philosophy of mind. Although the debts to, and the insight into, Wittgenstein are substantial, I do not wish to document (...) them. (shrink)

I Pletho's Date of Death In 1976 I denied the correctness of the commonly held date of 1452 for Pletho's death. I argued instead for 1454. The difference of two years meant not only that Pletho lived to see the fall of Constantinople in 1453, but also that a whole series of works in the Plato-Aristotle controversy had to be redated. The basis for the 1452 date is a notice found amid other notes by an unknown hand on the last (...) folio of the fifteenth-century manuscript M. 15 in the University Library in Salamanca and in another series of notes in the hand of Pletho's disciple and admirer Demetrius Raoul Kabakes on f. 50v of Gr. 495 of the Bayerisches Staatsbibliothek, Munich. With only trivial variation, both notes state that Master Gemistus died on the first hour of Monday, 26 June in the fifteenth Indiction. Since the only year in this period in which 26 June falls on a Monday in the fifteenth Indiction is 1452, Pletho's date of death seems well established. Though Kabakes was a bizarre character whose trademark was, in Bidez's phrase, an orthographe fantasiste, the fact that he wrote the notice in Munich Gr. 495 might be viewed as strenghtening its credibility. Futhermore, since Dositheus, Metropolitan of Monembasia seems to have died on 1 September 1452 and on blank folios (ff. 7v–8r) in MS Venice, Bibl. Marc., Zan. Gr. 333 (= 644) Bessarion wrote his memorial verses on Pletho and then his memorial verses on Dositheus, one can argue that in the summer of 1452 Bessarion first heard of Pletho's death and then a few months later of Dositheus'. Nonetheless, the death notice is certainly wrong. (shrink)

Whither the philosophy of intuition?Herman Cappelen’s Philosophy Without Intuitions (PWI) is a novel study in philosophical sociology—or, as Cappelen at one point suggests, “intellectual anthropology” (96).All undated references are to Cappelen (2012). Its target is the thesis that intuition is central, in the descriptive sense that contemporary analytic philosophers rely on intuitions for evidence—or, more generally, positive epistemic status. Cappelen labels the target thesis Centrality.If Centrality is true, then especially urgent are two questions in the rapidly growing field that is (...) the philosophy of intuition:[Q1] What are intuitions?[Q2] Can intuitions serve as evidence?There are of course others, but in chapter one Cappelen singles out these two as The Burning Questions about intuition. He then summarizes the overall upshot of PWI as follows:In this book I argue that Centrality, on any reasonable interpretation, is false. If you share that view, the Burning Questions will no lo .. (shrink)